BREDININ-INDUCED CHROMOSOME ABERRATIONS IN L5178Y CELLS
نویسندگان
چکیده
منابع مشابه
Effect of bredinin and its aglycone on L5178Y cells.
The aglycone of the nucleoside antibiotic, bredinin, was as strongly cytotoxic to L5178Y cells as bredinin. The cytotoxic properties of the aglycone were very similar to those of bredinin and the minimum inhibitory concentrations of both were 10(-5)M. The growth inhibitory effects of both agents regardless of their concentrations, were reversed by guanylic acid, guanosine or guanine. However, o...
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Chromosomal aberrations and dihydrofolate reductase gene amplification are observed in L5178Y mouse lymphoma cells after treatment with hydroxyurea. The types of aberrations include polyploidy, endoreduplication, chromosome fragmentation, and the presence of extrachromosomal DNA. Hydroxyurea-treated cells analyzed by cell sorting showed a subpopulation of cells with increased DNA and increased ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Genetics
سال: 1976
ISSN: 0021-504X,1880-5787
DOI: 10.1266/jjg.51.61